Exploring the cellular accumulation of metal complexes

Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described

Velocity Tails for Inelastic Maxwell Models

We study the velocity distribution function for inelastic Maxwell models, characterized by a Boltzmann equation with constant collision rate, independent of the energy of the colliding particles. By means of a nonlinear analysis of the Boltzmann equation, we find that the velocity distribution function decays algebraically for large velocities, with exponents that are analytically calculated.Comment: 4 pages, 2 figure

MEXIT: Maximal un-coupling times for stochastic processes

Classical coupling constructions arrange for copies of the \emph{same} Markov process started at two \emph{different} initial states to become equal as soon as possible. In this paper, we consider an alternative coupling framework in which one seeks to arrange for two \emph{different} Markov (or other stochastic) processes to remain equal for as long as possible, when started in the \emph{same} state. We refer to this "un-coupling" or "maximal agreement" construction as \emph{MEXIT}, standing for "maximal exit". After highlighting the importance of un-coupling arguments in a few key statistical and probabilistic settings, we develop an explicit \MEXIT construction for stochastic processes in discrete time with countable state-space. This construction is generalized to random processes on general state-space running in continuous time, and then exemplified by discussion of \MEXIT for Brownian motions with two different constant drifts.Comment: 28 page

Integrability of generalized (matrix) Ernst equations in string theory

The integrability structures of the matrix generalizations of the Ernst equation for Hermitian or complex symmetric $d\times d$-matrix Ernst potentials are elucidated. These equations arise in the string theory as the equations of motion for a truncated bosonic parts of the low-energy effective action respectively for a dilaton and $d\times d$ - matrix of moduli fields or for a string gravity model with a scalar (dilaton) field, U(1) gauge vector field and an antisymmetric 3-form field, all depending on two space-time coordinates only. We construct the corresponding spectral problems based on the overdetermined $2d\times 2d$-linear systems with a spectral parameter and the universal (i.e. solution independent) structures of the canonical Jordan forms of their matrix coefficients. The additionally imposed conditions of existence for each of these systems of two matrix integrals with appropriate symmetries provide a specific (coset) structures of the related matrix variables. An equivalence of these spectral problems to the original field equations is proved and some approach for construction of multiparametric families of their solutions is envisaged.Comment: 15 pages, no figures, LaTeX; based on the talk given at the Workshop ``Nonlinear Physics: Theory and Experiment. III'', 24 June - 3 July 2004, Gallipoli (Lecce), Italy. Minor typos, language and references corrections. To be published in the proceedings in Theor. Math. Phy

Efficient decoupling schemes with bounded controls based on Eulerian orthogonal arrays

The task of decoupling, i.e., removing unwanted interactions in a system Hamiltonian and/or couplings with an environment (decoherence), plays an important role in controlling quantum systems. There are many efficient decoupling schemes based on combinatorial concepts like orthogonal arrays, difference schemes and Hadamard matrices. So far these (combinatorial) decoupling schemes have relied on the ability to effect sequences of instantaneous, arbitrarily strong control Hamiltonians (bang-bang controls). To overcome the shortcomings of bang-bang control Viola and Knill proposed a method called Eulerian decoupling that allows the use of bounded-strength controls for decoupling. However, their method was not directly designed to take advantage of the composite structure of multipartite quantum systems. In this paper we define a combinatorial structure called an Eulerian orthogonal array. It merges the desirable properties of orthogonal arrays and Eulerian cycles in Cayley graphs (that are the basis of Eulerian decoupling). We show that this structure gives rise to decoupling schemes with bounded-strength control Hamiltonians that can be applied to composite quantum systems with few body Hamiltonians and special couplings with the environment. Furthermore, we show how to construct Eulerian orthogonal arrays having good parameters in order to obtain efficient decoupling schemes.Comment: 8 pages, revte